Nutrients August-2 2023 - Browse Articles

Chanel Le Vernis Nail Colour is a nail lacquer that retails for $28.00 and contains 0.4 oz. ($70.00 per ounce). There are 118 shades in our database.

Chanel Le Vernis Nail Colour • Nail Lacquer Review & Swatches

 Dopo un'attesa estenuante sono finalmente arrivati in tutte le profumerie, o quasi, gli smalti della collezione Avant Première de Chanel e per chi è rimasta delusa dagli smalti sicuramente troverà qualcosa d'interessante nei rossetti: ce n'è davvero per tutti i gusti! Le Vernis Cinèma 581 è una classica tonalità di rosso, leggermente aranciato, che ben…

Chanel Cinèma 581

Chanel Le Vernis Long Wear Nail Colour Reds, Review, Swatch

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Chanel Summer 2015 Nail Polish Swatches & Review : All Lacquered Up

Spatial and temporal dynamics of ATP synthase from mitochondria

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About one-third of individuals living with epilepsy have treatment-resistant seizures. Alternative therapeutic strategies are thus urgently needed. One potential novel treatment target is miRNA-induced silencing, which is differentially regulated in epilepsy. Inhibitors (antagomirs) of specific microRNAs (miRNAs) have shown therapeutic promise in preclinical epilepsy studies; however, these studies were mainly conducted in male rodent models, and research into miRNA regulation in females and by female hormones in epilepsy is scarce. This is problematic because female sex and the menstrual cycle can affect the disease course of epilepsy and may, therefore, also alter the efficacy of potential miRNA-targeted treatments. Here, we used the proconvulsant miRNA miR-324-5p and its target, the potassium channel Kv4.2, as an example to test how miRNA-induced silencing and the efficacy of antagomirs in epilepsy are altered in female mice. We showed that Kv4.2 protein is reduced after seizures in female mice similar to male mice; however, in contrast to male mice, miRNA-induced silencing of Kv4.2 is unchanged, and miR-324-5p activity, as measured by the association with the RNA-induced silencing complex, is reduced in females after seizure. Moreover, an miR-324-5p antagomir does not consistently reduce seizure frequency or increase Kv4.2 in female mice. As a possible underlying mechanism, we found that miR-324-5p activity and the silencing of Kv4.2 in the brain were differentially correlated with plasma levels of 17β-estradiol and progesterone. Our results suggest that hormonal fluctuations in sexually mature female mice influence miRNA-induced silencing and could alter the efficacy of potential future miRNA-based treatments for epilepsy in females.

Estradiol- and Progesterone-Associated Changes in microRNA-Induced

Retrieving the microphysical properties of opaque liquid water

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